Article
Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients.
The American journal of clinical nutrition - 1 Nov 2008
Guerreiro Catarina Sousa, Carmona Bruno, Gonçalves Susana, Carolino Elisabete, Fidalgo Paulo, Brito Miguel, Leitão Carlos Nobre, Cravo Marília
Abstract excerpt
BACKGROUND: Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated in colorectal cancer (CRC). OBJECTIVE: We evaluated the association of 3 genetic polymorphisms [C677T MTHFR (methylene tetrahydrofolate reductase), A2756G MTR (methionine synthase), and C1420T SHMT (serine hydroxymethyltransferase)] with the intake of methyl-donor nutrients in CRC risk....
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