Article
Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma.
International journal of colorectal disease - 1 Jul 2007
Lima Carmen S P, Nascimento Helvia, Bonadia Luciana C, Teori Maria T, Coy Claudio S R, Góes Juvenal R N, Costa Fernando F, Bertuzzo Carmen S
Abstract excerpt
BACKGROUND AND AIMS: Evidence is accumulating for a role of folate in the aetiology of colorectal cancer (CRC). The methylenetetrahydrofolate reductase (MTHFR) gene, involved in folate metabolism, is polymorphic in humans. Since it is unknown whether the MTHFR C677T and A1298C polymorphisms alter...
Topics
- Adenocarcinoma
- Age Factors
- Age of Onset
- Biomarkers, Tumor
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Genotype
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Neoplasm Staging
- Polymerase Chain Reaction