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Article

[Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of sporadic colorectal cancer].

The Pan African medical journal - 1 Jan 2021

Baghad Imane, Erreguibi Driss, Boufettal Rachid, Eljai Saad Rifki, Chihab Farid, Nadifi Sellama

Abstract excerpt

Colorectal cancer (CRC) is a major global public health problem. Folate metabolism is involved in DNA synthesis, repair and methylation. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Common MTHFR C677T polymorphism was correlated to CRC. This case-control study was conducted to analyze the association between this polymorphism and the risk of sporadic CRC in a Moroccan...

Topics

Adult
Alleles
Case-Control Studies
Colorectal Neoplasms
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morocco

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 34122714
DOI: 10.11604/pamj.2021.38.287.12522
PMCID: PMC8179987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34122714-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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