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Article

MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations.

International journal of cancer - 1 Mar 2007

Hubner Richard A, Houlston Richard S

Abstract excerpt

The common functional methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism may influence the risk of colorectal cancer (CRC), but data from published studies with individually low statistical power are conflicting. To clarify the role of MTHFR C677T genotype in CRC, we considered all available studies in a meta-analysis. Studies reporting on MTHFR C677T genotype and CRC were searched in PubMed up to...

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Source

Identifiers

PMID: 17131337
DOI: 10.1002/ijc.22440

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR C677T and colorectal cancer risk: A meta-analysis of 25 populations.PMID 17131337Read ↗

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.Semantic proximity Read ↗

MTHFR C677T polymorphism and colorectal cancer risk in Asians, a meta-analysis of 21 studies.Semantic proximity Read ↗

Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations.Semantic proximity Read ↗

The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies.Semantic proximity Read ↗

Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.Semantic proximity Read ↗

MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.Semantic proximity Read ↗

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