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Article

The LRRK2 R1628P variant plays a protective role in Han Chinese population with Alzheimer's disease.

CNS neuroscience & therapeutics - 1 Apr 2013

Li Hong-Lei, Lu Shen-Ji, Sun Yi-Min, Guo Qi-Hao, Sadovnick Adele Dessa, Wu Zhi-Ying

Abstract excerpt

AIMS: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders that may share some overlapping etiologies. Mutations within leucine-rich repeat kinase 2 (LRRK2) have been reported to be responsible for PD, and the location of LRRK2 is within a linkage peak for sporadic AD (SAD). The aim of this study was to investigate two Asian-specific LRRK2 variants, R1628P and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Polymorphism, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 23421816
DOI: 10.1111/cns.12062
PMCID: PMC6493338

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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