Article
LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
Movement disorders : official journal of the Movement Disorder Society - 15 Oct 2009
Zhang Zijuan, Burgunder Jean-Marc, An Xingkai, Wu Yan, Chen Wenjun, Zhang Jinhong, Wang Yingcheng, Xu Yanming, Gou Yingru, Yuan Guanggu, Mao Xueye, Peng Rong
Abstract excerpt
Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han-Chinese population from mainland China, we...
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