Article
The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population.
Neurogenetics - 1 Oct 2008
Lu Chin-Song, Wu-Chou Yah-Huei, van Doeselaar Marina, Simons Erik J, Chang Hsiu-Chen, Breedveld Guido J, Di Fonzo Alessio, Chen Rou-Shayn, Weng Yi-Hsin, Lai Szu-Chia, Oostra Ben A, Bonifati Vincenzo
Abstract excerpt
The c.G4883C variant in the leucine-rich repeat kinase 2 (LRRK2) gene (protein effect: Arg1628Pro) has been recently proposed as a second risk factor for sporadic Parkinson's disease in the Han Chinese population (after the Gly2385Arg variant). In this paper, we analyze the Arg1628Pro variant and the associated haplotype in a large sample of 1,337 Han subjects (834 patients and 543 controls) ascertained from a...
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