Article
LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.
Human genetics - 1 Oct 2008
Tan E K, Tan Louis C, Lim H Q, Li R, Tang M, Yih Yuen, Pavanni R, Prakash K M, Fook-Chong S, Zhao Yi
Abstract excerpt
We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4-...
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