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Article

Deregulated Nras expression in knock-in animals harboring a gammaretroviral long terminal repeat at the Nras/Csde1 locus.

PloS one - 1 Jan 2013

Ballarín-González Borja, Lassen Louise Berkhoudt, Jessen Randi, Füchtbauer Annette, Füchtbauer Ernst-Martin, Pedersen Finn Skou

Abstract excerpt

To investigate mechanisms and phenotypic effects of insertional mutagenesis by gammaretroviruses, we have developed mouse lines containing a single Akv 1-99 long terminal repeat (LTR) and a floxed PGK/Tn5 neomycin cassette at the Nras proto-oncogene at positions previously identified as viral integration sites in Akv 1-99 induced tumors. The insert did not compromise the embryonic development, however, the...

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Identifiers

PMID: 23418499
DOI: 10.1371/journal.pone.0056029
PMCID: PMC3572152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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