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Article

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.

Cancer research - 15 Apr 2008

Xu Xia, Page Jennifer L, Surtees Jennifer A, Liu Houchun, Lagedrost Sarah, Lu Young, Bronson Roderick, Alani Eric, Nikitin Alexander Yu, Weiss Robert S

Abstract excerpt

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in nucleotide biosynthesis and plays a central role in genome maintenance. Although a number of regulatory mechanisms govern RNR activity, the physiologic effect of RNR deregulation had not previously been examined in an animal model. We show here that overexpression of the small RNR subunit potently and selectively induces lung neoplasms in...

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Identifiers

PMID: 18413732
DOI: 10.1158/0008-5472.CAN-07-5873
PMCID: PMC2459241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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