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Article

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice.

Blood - 1 Oct 2006

Parikh Chaitali, Subrahmanyam Ramesh, Ren Ruibao

Abstract excerpt

Activating mutations in RAS, predominantly NRAS, are common in myeloid malignancies. Previous studies in animal models have shown that oncogenic NRAS is unable to induce myeloid malignancies effectively, and it was suggested that oncogenic NRAS might only act as a secondary mutation in leukemogenesis. In this study, we examined the leukemogenicity of NRAS using an improved mouse bone marrow transduction and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16763213
DOI: 10.1182/blood-2004-08-009498
PMCID: PMC1895567

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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