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Article

Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice.

PloS one - 1 Jan 2012

Lassen Louise Berkhoudt, Ballarín-González Borja, Schmitz Alexander, Füchtbauer Annette, Pedersen Finn Skou, Füchtbauer Ernst-Martin

Abstract excerpt

NRAS is a proto-oncogene involved in numerous myeloid malignancies. Here, we report on a mouse line bearing a single retroviral long terminal repeat inserted into Nras. This genetic modification resulted in an increased level of wild type Nras mRNA giving the possibility of studying the function...

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Identifiers

PMID: 22876308
DOI: 10.1371/journal.pone.0042216
PMCID: PMC3410918

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22876308-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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