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Article

Introduction of oncogenes into mammary glands <i>in vivo</i> with an avian retroviral vector initiates and promotes carcinogenesis in mouse models

7 Nov 2006

Abstract excerpt

We have adapted the avian leukosis virus RCAS (replication-competent avian sarcoma-leukosis virus LTR splice acceptor)-mediated somatic gene transfer technique to introduce oncogenes into mammary cells in mice transgenic for the avian subgroup A receptor gene, tva, under control of the mouse mammary tumor virus (MMTV) promoter. Intraductal instillation of an RCAS vector carrying the polyoma middle T antigen...

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PMID: 17090666
DOI: 10.1073/pnas.0608607103

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