Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.

Leukemia - 1 Aug 2018

Cramer Sarah D, Hixon Julie A, Andrews Caroline, Porter Ross J, Rodrigues Gisele O L, Wu Xiaolin, Back Tim, Czarra Kelli, Michael Helen, Cam Maggie, Chen Jack, Esposito Dominic, Senkevitch Emilee, Negi Vijay, Aplan Peter D, Li Wenqing, Durum Scott K

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Gene Expression Regulation, Leukemic
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Interleukin-7

Share to T-Lymphocytes

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 29535426
DOI: 10.1038/s41375-017-0001-0
PMCID: PMC7984718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.PMID 29535426Read ↗

Mechanism of co-operation of mutant IL-7Rα and mutant NRAS in acute lymphoblastic leukemia: role of MYC.Semantic proximity Read ↗

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.Semantic proximity Read ↗

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemiaSemantic proximity Read ↗

Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Mutations that collaborate with IL-7Ra signaling pathways to drive ALL.Semantic proximity Read ↗

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatmentSemantic proximity Read ↗

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

Deleterious and Oncogenic Mutations in the IL7RASemantic proximity Read ↗

IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.