Article
A functional variomics tool for discovering drug-resistance genes and drug targets.
Cell reports - 21 Feb 2013
Huang Zhiwei, Chen Kaifu, Zhang Jianhuai, Li Yongxiang, Wang Hui, Cui Dandan, Tang Jiangwu, Liu Yong, Shi Xiaomin, Li Wei, Liu Dan, Chen Rui, Sucgang Richard S, Pan Xuewen
Abstract excerpt
Comprehensive discovery of genetic mechanisms of drug resistance and identification of in vivo drug targets represent significant challenges. Here we present a functional variomics technology in the model organism Saccharomyces cerevisiae. This tool analyzes numerous genetic variants and effectively tackles both problems simultaneously. Using this tool, we discovered almost all genes that, due to mutations or...
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