Article
Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.
PLoS genetics - 1 Sept 2016
Wong Lai H, Sinha Sunita, Bergeron Julien R, Mellor Joseph C, Giaever Guri, Flaherty Patrick, Nislow Corey
Abstract excerpt
The emergence and prevalence of drug resistance demands streamlined strategies to identify drug resistant variants in a fast, systematic and cost-effective way. Methods commonly used to understand and predict drug resistance rely on limited clinical studies from patients who are refractory to drugs or on laborious evolution experiments with poor coverage of the gene variants. Here, we report an integrative...
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