Article
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013
Laurila Pirkka-Pekka, Surakka Ida, Sarin Antti-Pekka, Yetukuri Laxman, Hyötyläinen Tuulia, Söderlund Sanni, Naukkarinen Jussi, Tang Jing, Kettunen Johannes, Mirel Daniel B, Soronen Jarkko, Lehtimäki Terho, Ruokonen Aimo, Ehnholm Christian, Eriksson Johan G, Salomaa Veikko, Jula Antti, Raitakari Olli T, Järvelin Marjo-Riitta, Palotie Aarno, Peltonen Leena, Oresic Matej, Jauhiainen Matti, Taskinen Marja-Riitta, Ripatti Samuli
Abstract excerpt
OBJECTIVE: Low high-density lipoprotein cholesterol (HDL-C) is associated with cardiometabolic pathologies. In this study, we investigate the biological pathways and individual genes behind low HDL-C by integrating results from 3 high-throughput data sources: adipose tissue transcriptomics, HDL lipidomics, and dense marker genotypes from Finnish individuals with low or high HDL-C (n=450). APPROACH AND RESULTS: In...
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