Article
Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.
PLoS genetics - 1 Dec 2011
Khetarpal Sumeet A, Edmondson Andrew C, Raghavan Avanthi, Neeli Hemanth, Jin Weijun, Badellino Karen O, Demissie Serkalem, Manning Alisa K, DerOhannessian Stephanie L, Wolfe Megan L, Cupples L Adrienne, Li Mingyao, Kathiresan Sekar, Rader Daniel J
Abstract excerpt
Genome-wide association studies (GWAS) have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies are being utilized to catalogue the allelic spectrum at GWAS loci. The goal of these studies is to identify causative variants and missing heritability, including heritability due to low frequency and rare alleles with large phenotypic impact. Whereas rare...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.