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Article

HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.

Nature reviews. Cardiology - 1 Jan 2018

Rosenson Robert S, Brewer H Bryan, Barter Philip J, Björkegren Johan L M, Chapman M John, Gaudet Daniel, Kim Daniel Seung, Niesor Eric, Rye Kerry-Anne, Sacks Frank M, Tardif Jean-Claude, Hegele Robert A

Abstract excerpt

Plasma levels of HDL cholesterol (HDL-C) predict the risk of cardiovascular disease at the epidemiological level, but a direct causal role for HDL in cardiovascular disease remains controversial. Studies in animal models and humans with rare monogenic disorders link only particular HDL-associated mechanisms with causality, including those mechanisms related to particle functionality rather than cholesterol...

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Share to Cholesterol, HDL
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes, Cardiovascular Risks, and Lipoproteins

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Share to Genetic Predisposition to Disease

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Source

Identifiers

PMID: 28795686
DOI: 10.1038/nrcardio.2017.115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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