Article
Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.
BMC medicine - 10 Sept 2021
Harshfield Eric L, Fauman Eric B, Stacey David, Paul Dirk S, Ziemek Daniel, Ong Rachel M Y, Danesh John, Butterworth Adam S, Rasheed Asif, Sattar Taniya, Zameer-Ul-Asar, Saleem Imran, Hina Zoubia, Ishtiaq Unzila, Qamar Nadeem, Mallick Nadeem Hayat, Yaqub Zia, Saghir Tahir, Rizvi Syed Nadeem Hasan, Memon Anis, Ishaq Mohammad, Rasheed Syed Zahed, Memon Fazal-Ur-Rehman, Jalal Anjum, Abbas Shahid, Frossard Philippe, Saleheen Danish, Wood Angela M, Griffin Julian L, Koulman Albert
Abstract excerpt
BACKGROUND: Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk is often unclear. Moreover, little is known about the role of lipids on cardiovascular disease in Pakistan, a population historically underrepresented in...
Topics
- Asian People
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lipids
- Myocardial Infarction
- Polymorphism, Single Nucleotide