Article
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels.
The EMBO journal - 6 Mar 2013
Sauguet Ludovic, Poitevin Frédéric, Murail Samuel, Van Renterghem Catherine, Moraga-Cid Gustavo, Malherbe Laurie, Thompson Andrew W, Koehl Patrice, Corringer Pierre-Jean, Baaden Marc, Delarue Marc
Abstract excerpt
To understand the molecular mechanism of ion permeation in pentameric ligand-gated ion channels (pLGIC), we solved the structure of an open form of GLIC, a prokaryotic pLGIC, at 2.4 Å. Anomalous diffraction data were used to place bound anions and cations. This reveals ordered water molecules at the level of two rings of hydroxylated residues (named Ser6' and Thr2') that contribute to the ion selectivity filter....
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