Article
An internal water-retention site in the rhomboid intramembrane protease GlpG ensures catalytic efficiency.
Structure (London, England : 1993) - 3 Jul 2012
Zhou Yanzi, Moin Syed M, Urban Sinisa, Zhang Yingkai
Abstract excerpt
Rhomboid proteases regulate key cellular pathways, but their biochemical mechanism including how water is made available to the membrane-immersed active site remains ambiguous. We performed four prolonged molecular dynamics simulations initiated from both gate-open and gate-closed states of Escherichia coli rhomboid GlpG in a phospholipid bilayer. GlpG was notably stable in both gating states, experiencing...
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