Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.

Abstract excerpt

Members of the TMEM16/ANO family of membrane proteins are Ca2+-activated phospholipid scramblases and/or Cl- channels. A membrane-exposed hydrophilic groove in these proteins serves as a shared translocation pathway for ions and lipids. However, the mechanism by which lipids gain access to and permeate through the groove remains poorly understood. Here, we combine quantitative scrambling assays and molecular...

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• Anoctamins
• Extracellular Space
• Hydrophobic and Hydrophilic Interactions
• Ion Channel Gating
• Ions