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Article

Structural cavities are critical to balancing stability and activity of a membrane-integral enzyme.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2020

Guo Ruiqiong, Cang Zixuan, Yao Jiaqi, Kim Miyeon, Deans Erin, Wei Guowei, Kang Seung-Gu, Hong Heedeok

Abstract excerpt

Packing interaction is a critical driving force in the folding of helical membrane proteins. Despite the importance, packing defects (i.e., cavities including voids, pockets, and pores) are prevalent in membrane-integral enzymes, channels, transporters, and receptors, playing essential roles in function. Then, a question arises regarding how the two competing requirements, packing for stability vs. cavities for...

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Identifiers

PMID: 32848056
DOI: 10.1073/pnas.1917770117
PMCID: PMC7486710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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