Article

Ligand-induced motions in pentameric ligand-gated ion channels revealed by EPR spectroscopy

2020-11-05

Abstract excerpt

Signaling in the brain depends on rapid opening and closing of pentameric ligand-gated ion channels (pLGICs). These proteins are the targets of various clinical drugs and, defects in their function is linked to a variety of diseases including myasthenia, epilepsy and sleep-disorders. While recent high-resolution structures of prokaryotic and eukaryotic pLGICs have shed light on the molecular architecture of these...

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Literature Corpus work: 5d2dafe8-a3b3-58fb-b60a-53b60edfe13f
DOI: 10.1101/2020.11.04.368233

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