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Article

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences.

Human genomics - 28 Feb 2023

Zhou Yitian, Nevosadová Lenka, Eliasson Erik, Lauschke Volker M

Abstract excerpt

BACKGROUND: Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin and multiple non-steroidal anti-inflammatory drugs (NSAIDs). A global map of CYP2C9 variability and its inferred functional consequences has been lacking. RESULTS: Frequencies of eight functionally relevant...

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Identifiers

PMID: 36855170
DOI: 10.1186/s40246-023-00461-z
PMCID: PMC9976394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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