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Article

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2013

Zikherman Julie, Parameswaran Ramya, Hermiston Michelle, Weiss Arthur

Abstract excerpt

CD45 is a receptor-like tyrosine phosphatase that positively regulates BCR signaling by dephosphorylating the inhibitory tyrosine of the Src family kinases. We showed previously that a single point mutation, E613R, introduced into the cytoplasmic membrane-proximal "wedge" domain of CD45 is sufficient to drive a lupus-like autoimmune disease on a susceptible genetic background. To clarify the molecular mechanism...

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Source

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Identifiers

PMID: 23396948
DOI: 10.4049/jimmunol.1202928
PMCID: PMC3593789

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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