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Article

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2013

Zikherman Julie, Parameswaran Ramya, Hermiston Michelle, Weiss Arthur

Abstract excerpt

CD45 is a receptor-like tyrosine phosphatase that positively regulates BCR signaling by dephosphorylating the inhibitory tyrosine of the Src family kinases. We showed previously that a single point mutation, E613R, introduced into the cytoplasmic membrane-proximal "wedge" domain of CD45 is sufficient to drive a lupus-like autoimmune disease on a susceptible genetic background. To clarify the molecular mechanism...

Topics

Alleles
Animals
B-Lymphocyte Subsets
Genetic Variation
Immune Tolerance
Leukocyte Common Antigens
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Receptor-Like Protein Tyrosine Phosphatases

Substrate Specificity

src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 23396948
DOI: 10.4049/jimmunol.1202928
PMCID: PMC3593789

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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