Article
An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
Cell - 22 Dec 2000
Majeti R, Xu Z, Parslow T G, Olson J L, Daikh D I, Killeen N, Weiss A
Abstract excerpt
A model has been proposed for the regulation of CD45, and by homology other RPTPs, in which dimerization inhibits phosphatase activity through symmetrical interactions between an inhibitory structural wedge and the catalytic site. Here, we report the phenotype of mice with a single point mutation, glutamate 613 to arginine, that inactivates the inhibitory wedge of CD45. The CD45 E613R mutation causes polyclonal...
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