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Article

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2009

Zikherman Julie, Hermiston Michelle, Steiner David, Hasegawa Kiminori, Chan Andrew, Weiss Arthur

Abstract excerpt

Pep and CD45 are tyrosine phosphatases whose targets include the Src-family kinases, critical mediators of Ag receptor signaling. A polymorphism in PTPN22, the gene that encodes the human Pep orthologue Lyp, confers susceptibility to multiple human autoimmune diseases in the context of complex genetic backgrounds. However, the functional significance of the R620W risk allele is not clear. We report that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19299707
DOI: 10.4049/jimmunol.0803317
PMCID: PMC2765978

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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