Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.

Genetics - 1 Aug 2013

Sasanuma Hiroyuki, Furihata Yuko, Shinohara Miki, Shinohara Akira

Abstract excerpt

Homologous recombination is associated with the dynamic assembly and disassembly of DNA-protein complexes. Assembly of a nucleoprotein filament comprising ssDNA and the RecA homolog, Rad51, is a key step required for homology search during recombination. The budding yeast Srs2 DNA translocase is known to dismantle Rad51 filament in vitro. However, there is limited evidence to support the dismantling activity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomes, Fungal
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homologous Recombination

Share to Prophase

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Share to Replication Protein A

Source

Open in PubMed Open full text

Identifiers

PMID: 23770697
DOI: 10.1534/genetics.113.150615
PMCID: PMC3730916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.PMID 23770697Read ↗

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Semantic proximity Read ↗

Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2.Semantic proximity Read ↗

Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2.Semantic proximity Read ↗

Dual role of Arabidopsis SRS2 helicase in meiotic recombinationSemantic proximity Read ↗

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.Semantic proximity Read ↗

Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.Semantic proximity Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA.Semantic proximity Read ↗

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast.Semantic proximity Read ↗

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.Semantic proximity Read ↗

Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.