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Article

Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.

PLoS genetics - 26 Feb 2010

Saponaro Marco, Callahan Devon, Zheng Xiuzhong, Krejci Lumir, Haber James E, Klein Hannah L, Liberi Giordano

Abstract excerpt

Cdk1 kinase phosphorylates budding yeast Srs2, a member of UvrD protein family, displays both DNA translocation and DNA unwinding activities in vitro. Srs2 prevents homologous recombination by dismantling Rad51 filaments and is also required for double-strand break (DSB) repair. Here we examine the biological significance of Cdk1-dependent phosphorylation of Srs2, using mutants that constitutively express the...

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Share to CDC28 Protein Kinase, S cerevisiae
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Helicases

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Share to Proliferating Cell Nuclear Antigen

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Share to Small Ubiquitin-Related Modifier Proteins

Source

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Identifiers

PMID: 20195513
DOI: 10.1371/journal.pgen.1000858
PMCID: PMC2829061

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.PMID 20195513Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Semantic proximity Read ↗

Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity.Semantic proximity Read ↗

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin.Semantic proximity Read ↗

Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2.Semantic proximity Read ↗

Srs2 plays a critical role in reversible G2 arrest upon chronic and low doses of UV irradiation via two distinct homologous recombination-dependent mechanisms in postreplication repair-deficient cells.Semantic proximity Read ↗

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.Semantic proximity Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesis.Semantic proximity Read ↗

Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2.Semantic proximity Read ↗

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA.Semantic proximity Read ↗

The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation.Semantic proximity Read ↗

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