Article
HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.
Cell metabolism - 5 Feb 2013
White Carine, Yuan Xiaojing, Schmidt Paul J, Bresciani Erica, Samuel Tamika K, Campagna Dean, Hall Caitlin, Bishop Kevin, Calicchio Monica L, Lapierre Ariane, Ward Diane M, Liu Paul, Fleming Mark D, Hamza Iqbal
Abstract excerpt
Adult humans have about 25 trillion red blood cells (RBCs), and each second we recycle about 5 million RBCs by erythrophagocytosis (EP) in macrophages of the reticuloendothelial system. Despite the central role for EP in mammalian iron metabolism, the molecules and pathways responsible for heme trafficking during EP remain unknown. Here, we show that the mammalian homolog of HRG1, a transmembrane heme permease in...
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