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Article

A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.

The Journal of biological chemistry - 10 Dec 2010

Sinclair Jason, Hamza Iqbal

Abstract excerpt

Hemes are prosthetic groups that participate in diverse biochemical pathways across phylogeny. Although heme can also regulate broad physiological processes by directly modulating gene expression in Metazoa, the regulatory pathways for sensing and responding to heme are not well defined. Caenorhabditis elegans is a heme auxotroph and relies solely on environmental heme for sustenance. Worms respond to heme...

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Identifiers

PMID: 20938051
DOI: 10.1074/jbc.M110.167619
PMCID: PMC2998115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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