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Article

Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney

24 Sept 2018

Abstract excerpt

Heme-iron recycling from senescent red blood cells (erythrophagocytosis) accounts for the majority of total body iron in humans. Studies in cultured cells have ascribed a role for HRG1/SLC48A1 in heme-iron transport but the in vivo function of this heme transporter is unclear. Here we present genetic evidence in a zebrafish model that Hrg1 is essential for macrophage-mediated heme-iron recycling during...

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Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobinopathies and Related Disorders
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PMID: 30248094
DOI: 10.1371/journal.pgen.1007665

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