Article

Hemozoin produced by mammals confers heme tolerance

2019-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Free heme is cytotoxic as exemplified by hemolytic diseases and genetic deficiencies in heme recycling and detoxifying pathways. Thus, intracellular accumulation of heme has not been observed in mammalian cells to date. Here we show that mice deficient for the heme transporter HRG1 accumulate over ten-fold excess heme in reticuloendothelial macrophage lysosomes that are 10 to 100 times larger th...

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Literature Corpus work: 2ffe600e-91c5-5228-9b99-7b536ca36d8c
DOI: 10.1101/629725

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