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Article

Topologically conserved residues direct heme transport in HRG-1-related proteins.

The Journal of biological chemistry - 10 Feb 2012

Yuan Xiaojing, Protchenko Olga, Philpott Caroline C, Hamza Iqbal

Abstract excerpt

Caenorhabditis elegans and human HRG-1-related proteins are conserved, membrane-bound permeases that bind and translocate heme in metazoan cells via a currently uncharacterized mechanism. Here, we show that cellular import of heme by HRG-1-related proteins from worms and humans requires strategic...

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Identifiers

PMID: 22174408
DOI: 10.1074/jbc.M111.326785
PMCID: PMC3281596

Genes

HRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22174408-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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