Article

A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis

2026-08-03

Abstract excerpt

Metabolic homeostasis depends on adaptive control of intracellular metabolite flux, yet how such control is reconfigured when canonical transport pathways fail is unknown. Here we define a conserved vesicular circuit that preserves systemic heme balance by rerouting intracellular heme flux. We show that loss of the intestinal heme exporter MRP-5 in Caenorhabditis elegans causes lethal heme sequestration within en...

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Literature Corpus work: 4b1adf8b-0371-59a3-97d5-b10717f4a0c1
DOI: 10.64898/2026.07.31.742071

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