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Article

Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response.

Pharmacogenomics - 1 Feb 2013

Pu Mengjia, Zhang Zhijun, Xu Zhi, Shi Yanyan, Geng Leiyu, Yuan Yonggui, Zhang Xiangrong, Reynolds Gavin P

Abstract excerpt

AIM: To investigate the role of genetic polymorphisms in glutamatergic and GABAergic genes and their interactions with environmental stressors in antidepressant response. METHODS: A set of 114 SNPs of 34 glutamatergic and GABAergic genes, mainly in promoter and coding regions, were genotyped in 281 Chinese Han major depressive disorder patients. The 17-item Hamilton Depression Rating Scale was used to evaluate...

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Source

Identifiers

PMID: 23394390
DOI: 10.2217/pgs.13.1

Genes

GABRP
GRIK4
GABRA6
GABRD
GABRE
GABRQ
GAD1
GRIA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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