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Article

The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.

Translational psychiatry - 25 Feb 2026

Illius Sabrina, Eder Julian, Vogel Susanne, Alexander Nina

Abstract excerpt

BACKGROUND: According to the diathesis-stress model, genetic liability and environmental exposures interact in the pathogenesis of depression. Polygenic risk scores for depression (PRSD) based on large-scale genome-wide association studies have opened new avenues for investigating gene-environment interaction (GxE) beyond candidate gene studies. To the best of our knowledge, this is the first systematic review of...

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Identifiers

PMID: 41741414
DOI: 10.1038/s41398-025-03793-7
PMCID: PMC12960946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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