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Article

Significance of risk polymorphisms for depression depends on stress exposure.

Scientific reports - 2 Mar 2018

Gonda Xenia, Hullam Gabor, Antal Peter, Eszlari Nora, Petschner Peter, Hökfelt Tomas Gm, Anderson Ian Muir, Deakin John Francis William, Juhasz Gabriella, Bagdy Gyorgy

Abstract excerpt

Depression is a polygenic and multifactorial disorder where environmental effects exert a significant impact, yet most genetic studies do not consider the effect of stressors which may be one reason for the lack of replicable results in candidate gene studies, GWAS and between human studies and animal models. Relevance of functional polymorphisms in seven candidate genes previously implicated in animal and human...

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Identifiers

PMID: 29500446
DOI: 10.1038/s41598-018-22221-z
PMCID: PMC5834495

Genes

BDNF
GALR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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