Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD.

doi:10.1002/ajmg.b.32593

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Article

Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2018

Van der Auwera Sandra, Peyrot Wouter J, Milaneschi Yuri, Hertel Johannes, Baune Bernhard, Breen Gerome, Byrne Enda, Dunn Erin C, Fisher Helen, Homuth Georg, Levinson Douglas, Lewis Cathryn, Mills Natalie, Mullins Niamh, Nauck Matthias, Pistis Giorgio, Preisig Martin, Rietschel Marcella, Ripke Stephan, Sullivan Patrick, Teumer Alexander, Völzke Henry, Boomsma Dorret I, Wray Naomi R, Penninx Brenda, Grabe Hans

Abstract excerpt

Gene by environment (GxE) interaction studies have investigated the influence of a number of candidate genes and variants for major depressive disorder (MDD) on the association between childhood trauma and MDD. Most of these studies are hypothesis driven and investigate only a limited number of SNPs in relevant pathways using differing methodological approaches. Here (1) we identified 27 genes and 268 SNPs...

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PMID: 29159863
DOI: 10.1002/ajmg.b.32593
PMCID: PMC5726923

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