Article
Several HLA alleles share overlapping peptide specificities.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1995
Sidney J, del Guercio M F, Southwood S, Engelhard V H, Appella E, Rammensee H G, Falk K, Rötzschke O, Takiguchi M, Kubo R T
Abstract excerpt
Herein we describe the establishment of assays to measure peptide binding to purified HLA-B*0701, -B*0801, -B*2705, -B*3501-03, -B*5401, -Cw*0401, -Cw*0602, and -Cw*0702 molecules. The binding of known peptide epitopes or naturally processed peptides correlates well with HLA restriction or origin...
Topics
- Alleles
- Amino Acid Sequence
- Cell Line, Transformed
- Consensus Sequence
- Epitopes
- Genes, MHC Class I
- HLA-B Antigens
- HLA-C Antigens
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Protein Binding
- Protein Structure, Tertiary
- Structure-Activity Relationship
- Substrate Specificity