Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1.

doi:10.1371/journal.pone.0111816

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Article

Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1.

PloS one - 1 Jan 2014

Würtz Morten, Nissen Peter H, Grove Erik Lerkevang, Kristensen Steen Dalby, Hvas Anne-Mette

Abstract excerpt

BACKGROUND: Platelet aggregation during aspirin treatment displays considerable inter-individual variability. A genetic etiology likely exists, but it remains unclear to what extent genetic polymorphisms determine platelet aggregation in aspirin-treated individuals. AIM: To identify platelet-rela...

Topics

Aged
Aspirin
Coronary Artery Disease
Cyclooxygenase 1
Female
Genotype
Humans
Male
Platelet Aggregation
Polymorphism, Single Nucleotide
Receptors, Cell Surface

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