Study of the Association of PEAR1, P2Y12, and UGT2A1 Polymorphisms with Platelet Reactivity in Response to Dual Antiplatelet Therapy in Chinese Patients.

doi:10.1159/000488101

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Article

Study of the Association of PEAR1, P2Y12, and UGT2A1 Polymorphisms with Platelet Reactivity in Response to Dual Antiplatelet Therapy in Chinese Patients.

Cardiology - 1 Jan 2018

Zhang Suli, Zhu Jinhang, Li Hua, Wang Lei, Niu Jiamin, Zhu Bin, He Lin, Shen Lu, Qin Shengying, Fang Shuxin

Abstract excerpt

OBJECTIVES: Genetic variation is thought to contribute to considerable interindividual variability in platelet function, and there is a pressing need to identify genetic markers that can be used to predict the response to treatment. Our study investigated whether PEAR1, P2Y12, and UGT2A1 polymorphisms were associated with platelet reactivity in response to dual antiplatelet therapy in Chinese patients with acute...

Topics

Acute Coronary Syndrome
Aged
Alleles
Asian People
Aspirin
Blood Platelets
China
Clopidogrel
Female
Glucuronosyltransferase
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Middle Aged

Multivariate Analysis

Percutaneous Coronary Intervention

Platelet Aggregation

Platelet Aggregation Inhibitors

Source

Open in PubMed

Identifiers

PMID: 29635252
DOI: 10.1159/000488101

Genes

PEAR1
HPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29635252-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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