Article

A transcriptome-wide Mendelian randomization study in isolated human immune cells highlights risk genes involved in viral infections and potential drug repurposing opportunities for schizophrenia

2024-02-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Schizophrenia is a neurodevelopmental psychiatric disorder characterised by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (i.e., causal, correlated, consequential) and the mechanisms involved are not fully understood. <h4>Methods</h4> To elucidate these mechanis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b70ad119-786d-576b-a67d-83b7ceafafc7
DOI: 10.1101/2024.02.18.24303002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A transcriptome-wide Mendelian randomization study in isolated human immune cells highlights risk genes involved in viral infections and potential drug repurposing opportunities for schizophreniaDOI 10.1101/2024.02.18.24303002Read

A Transcriptome-Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia.Semantic proximity Read

Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study.Semantic proximity Read

Common variants of IRF3 conferring risk of schizophrenia.Semantic proximity Read

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.Semantic proximity Read

Genetic Evidence for a Neuroimmune Model of Schizophrenia.Semantic proximity Read

Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders.Semantic proximity Read

Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis.Semantic proximity Read

Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cellsSemantic proximity Read

The causal relationship between immune cell traits and schizophrenia: a Mendelian randomization analysis.Semantic proximity Read

Identifying circulating protein targets for common factors underlying schizophrenia, depression, and bipolar disorderSemantic proximity Read

Immunogenetic Variants in Major Mental and Neurodevelopmental Disorders.Semantic proximity Read

Genomics-driven integrative analysis highlights immune-related plasma proteins for psychiatric disorders.Semantic proximity Read