Back to search

Article

Inflammation increases the penetrance of behavioral impairment in <i>Shank3</i> haploinsufficiency mice – can it explain the behavioral regression in Autism?

2025-08-11

Abstract excerpt

Behavioral regression occurs in ∼40% of SHANK3 -associated autism spectrum disorder (ASD). We previously reported that significant behavioral regression in a small cohort with SHANK3 haploinsufficiency patients, triggered by subclinical infections, responded to immunomodulator treatments. We hypothesize that behavioral regression results from the interplay between SHANK3 deficiency and neuroinflammation. Using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef6c0f76-1948-5867-a3a3-91cc75229e80
DOI
10.1101/2025.08.07.669241
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inflammation increases the penetrance of behavioral impairment in <i>Shank3</i> haploinsufficiency mice – can it explain the behavioral regression in Autism?DOI 10.1101/2025.08.07.669241
Inhibition of TRPV4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of AutismSemantic proximity
Early Restoration of Shank3 Expression in Shank3 Knock-Out Mice Prevents Core ASD-Like Behavioral Phenotypes.Semantic proximity
Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications.Semantic proximity
Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse ModelSemantic proximity
Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.Semantic proximity
Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.Semantic proximity
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.Semantic proximity
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.Semantic proximity
Transcriptional Determinism and Stochasticity Contribute to the Complexity of Autism Associated <i>SHANK</i> Family GenesSemantic proximity
Behavioral phenotyping of an improved mouse model of Phelan-McDermid Syndrome with a complete deletion of the <i>Shank3</i> geneSemantic proximity
Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice.Semantic proximity
Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder.Semantic proximity
Select a neighboring publication to make it the new centre.