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Article

BBOX1 is down-regulated in maternal immune-activated mice and implicated in genetic susceptibility to human schizophrenia.

Psychiatry research - 1 Jan 2018

Lee Hwayoung, Kim Hyung-Ki, Kwon Jun-Tack, Park Shohyun, Park Hae Jeong, Kim Su Kang, Park Jin Kyung, Kang Won Sub, Kim Young Jong, Chung Joo-Ho, Kim Jong Woo, Kim Hak-Jae

Abstract excerpt

Prenatal exposure to infectious or inflammatory insults can increase the risk of developing neuropsychiatric disorders such as bipolar disorder, autism, and schizophrenia in later life. Gamma-butyrobetaine hydroxylase (BBOX 1) is an enzyme responsible for the biosynthesis of l-carnitine, a key molecule in fatty acid metabolism. This cytosolic dimeric protein belongs to the dioxygenase family. In this study, we...

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Identifiers

PMID: 29065368
DOI: 10.1016/j.psychres.2017.10.018

Genes

BBOX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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