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Article

MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.

Molecular psychiatry - 1 Jan 2018

Mitchell A C, Javidfar B, Pothula V, Ibi D, Shen E Y, Peter C J, Bicks L K, Fehr T, Jiang Y, Brennand K J, Neve R L, Gonzalez-Maeso J, Akbarian S

Abstract excerpt

Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast amounts of molecular information, with largely unexplored therapeutic potential. We harnessed publically available information from the Psychiatric Genomics Consortium, and report myocyte enhancer factor 2C (MEF2C) motif enrichment in sequences surrounding the top scoring single-nucleotide polymorphisms within risk loci...

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Identifiers

PMID: 28115742
DOI: 10.1038/mp.2016.254
PMCID: PMC5966823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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