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Article

Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy

7 Feb 2013

Abstract excerpt

The Notch pathway is an evolutionarily conserved signaling cascade that is critical in kidney development and has also been shown to play a pathogenetic role in a variety of kidney diseases. We have previously shown that the Notch signaling pathway is activated in human immunodeficiency virus-associated nephropathy (HIVAN) as well as in a rat model of the disease. In this study, we examined Notch signaling in the...

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PMID: 23389453
DOI: 10.1152/ajprenal.00475.2012

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