Article
Critical role for Nef in HIV-1-induced podocyte dedifferentiation.
Kidney international - 1 Nov 2003
Sunamoto Masaaki, Husain Mohammad, He John Cijiang, Schwartz Elissa J, Klotman Paul E
Abstract excerpt
The notable glomerular feature of human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) is the collapse of the capillary tuft with marked glomerular epithelial cell hyperplasia. These data suggest a loss of normal podocyte function, which is associated with a loss of the podocyte differentiation markers, Wilm's tumor (WT-1), synaptopodin, podocalyxin, and common acute lymphoblastic leukemia antigen...
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